Imaging in cancer immunology:phenotyping immune cell subsets in situ in FFPE tissue sections.
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چکیده
منابع مشابه
Bovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
Abstract Introduction: Bovine leukemia virus (BLV) causes enzootic bovine leukemia, andis closely related to human T-lymphotropic virus type 1. It expresses microRNAs of unknown function and codes Tax, the protein that mediates malignant transformation. BLV is capable of infecting B- and T-lymphocytes, endothelial cells, and mammary epithelial cells of cattle. Several studies demonstrated the ...
متن کاملBovine Leukemia Virus Presence in Breast Tissue of Argentinian Females and Its Association With Cell Proliferation and Prognosis Markers
Abstract Introduction: Bovine leukemia virus (BLV) causes enzootic bovine leukemia, andis closely related to human T-lymphotropic virus type 1. It expresses microRNAs of unknown function and codes Tax, the protein that mediates malignant transformation. BLV is capable of infecting B- and T-lymphocytes, endothelial cells, and mammary epithelial cells of cattle. Several studies demonstrated the ...
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Background Full realization of the potential of immunotherapy will require biomarkers that capture immuno-tumor interactions. This will most effectively be achieved by phenotyping cells in-situ in intact tissue sections. Such methods will potentially predict response to drugs and monitor efficacy and onset of resistance. Existing methods are limited. Here we report a novel integrated approach, ...
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Background Recent successes with experimental PD-L1 and PD-1 drugs and with adoptive immunotherapy point to the tremendous potential clinical value of harnessing our immune systems to fight cancer. Assessing host interaction with malignant cells is most effectively achieved by phenotyping cell types in-situ in intact tissue sections. Spatial relationships and phenotype patterns can potentially ...
متن کاملDirect analysis and MALDI imaging of formalin-fixed, paraffin-embedded tissue sections.
Formalin fixation, generally followed by paraffin embedding, is the standard and well-established processing method employed by pathologist. This treatment conserves and stabilizes biopsy samples for years. Analysis of FFPE tissues from biopsy libraries has been, so far, a challenge for proteomics biomarker studies. Herein, we present two methods for the direct analysis of formalin-fixed, paraf...
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ورودعنوان ژورنال:
- MLO: medical laboratory observer
دوره 46 6 شماره
صفحات -
تاریخ انتشار 2014